Prostaglandin and myokine involvement in the cyclooxygenase-inhibiting drug enhancement of skeletal muscle adaptations to resistance exercise in older adults.

@article{Trappe2013ProstaglandinAM,
  title={Prostaglandin and myokine involvement in the cyclooxygenase-inhibiting drug enhancement of skeletal muscle adaptations to resistance exercise in older adults.},
  author={Todd A. Trappe and Robert A. Standley and Bozena Jemiolo and Chad C. Carroll and Scott W. Trappe},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2013},
  volume={304 3},
  pages={R198-205}
}
Twelve weeks of resistance training (3 days/wk) combined with daily consumption of the cyclooxygenase-inhibiting drugs acetaminophen (4.0 g/day; n = 11, 64 ± 1 yr) or ibuprofen (1.2 g/day; n = 13, 64 ± 1 yr) unexpectedly promoted muscle mass and strength gains 25-50% above placebo (n = 12, 67 ± 2 yr). To investigate the mechanism of this adaptation, muscle biopsies obtained before and ∼72 h after the last training bout were analyzed for mRNA levels of prostaglandin (PG)/cyclooxygenase pathway… CONTINUE READING
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Adolph distinguished lecture: muscle as an endocrine organ: IL-6 and other myokines

  • F. Pedersen BK. Edward
  • J Appl Physiol
  • 2009
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