Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells.

@article{Chinery1999ProstaglandinJA,
  title={Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells.},
  author={Rebecca Chinery and Robert J Coffey and Ramona Graves-Deal and Susan C. Kirkland and Stephanie C. Sanchez and William E. Zackert and John A. Oates and Jason D. Morrow},
  journal={Cancer research},
  year={1999},
  volume={59 11},
  pages={2739-46}
}
Increased expression of cyclooxygenase (COX) and overproduction of prostaglandins (PGs) have been implicated in the development and progression of colorectal cancer (CRC). Nonsteroidal anti-inflammatory agents (NSAIDS) inhibit growth of various CRC cell lines by both COX-dependent and COX-independent pathways. To specifically examine the effect of COX and PGs on proliferation in CRC cells, we introduced an antisense COX-2 cDNA construct under the control of a tetracycline (Tc)-inducible… CONTINUE READING

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