Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26 S proteasome assembly in human neuroblastoma cells.

@article{Wang2006ProstaglandinJA,
  title={Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26 S proteasome assembly in human neuroblastoma cells.},
  author={Zhiyou Wang and Virginie M. Aris and Kenyon D Ogburn and Patricia Soteropoulos and Maria E Figueiredo-Pereira},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 30},
  pages={21377-86}
}
Many neurodegenerative disorders are characterized by two pathological hallmarks: progressive loss of neurons and occurrence of inclusion bodies containing ubiquitinated proteins. Inflammation may be critical to neurodegeneration associated with ubiquitin-protein aggregates. We previously showed that prostaglandin J2 (PGJ2), one of the endogenous products of inflammation, induces neuronal death and the accumulation of ubiquitinated proteins into distinct aggregates. We now report that temporal… CONTINUE READING
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