Prostaglandin I2 mediates contraction and relaxation of vascular smooth muscle.

@article{Williams1994ProstaglandinIM,
  title={Prostaglandin I2 mediates contraction and relaxation of vascular smooth muscle.},
  author={Shawn P. Williams and Gerald W. Dorn and Robert M. Rapoport},
  journal={The American journal of physiology},
  year={1994},
  volume={267 2 Pt 2},
  pages={
          H796-803
        }
}
Prostaglandin (PG) I2 elicits a biphasic concentration-response curve in rat aorta: lower concentrations elicit relaxation, whereas at higher concentrations, the relaxation is reversed. The purpose of this study was to investigate 1) the nature of the receptors that mediate these effects and 2) whether the relaxant efficacy of PGI2 is decreased at higher PGI2 concentrations by PGI2-induced contraction. PGI2 (1 microM), the stable PGI2 analogue carbacyclin (1 microM), and PGE1 (3 microM) induced… CONTINUE READING

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