Prostaglandin I2 as a potentiator of acute inflammation in rats.

  title={Prostaglandin I2 as a potentiator of acute inflammation in rats.},
  author={Keiji Komoriya and Hitoshi Ohmori and Akiko Azuma and Seizi Kurozumi and Yoshinobu Hashimoto and Kyriacos C Nicolaou and William E. Barnette and Ronald L. Magolda},
  volume={15 4},

Arachidonic acid peroxidation in inflammation and its inhibition as a mechanism for anti-inflammatory activity

It is 10 years since arachidonic acid metabolism was first associated with the development of the inflammatory response and the discovery that aspirin and other non-steroid anti-inflammatory drugs selectively inhibit prostaglandin symthesis led to Vane's now famous theory that inhibition of prostaglandsin biosynthesis explains the therapeutic and toxic effects of aspirin-like drugs.

Effect of 6,9-thia prostaglandin I2 (a stable PGI2 analogue) on passive cutaneous anaphylaxis (PCA) in rats.

Prostaglandin I2 potentiation by PGI2 of increased vascular permeability induced by histamine in rats treated with carrageenin is reported.

Modulation of Acute Allergic Inflammation by Prostaglandins

In the hamster cheek pouch model of allergic inflammation, inhibition of mediator release by endogenous prostaglandins predominates, however, the final outcome of these opposite actions of vasodilating prostanoids is likely to vary with differences in experimental design.



Prostaglandins as Potentiators of Increased Vascular Permeability in Inflammation

It is concluded that in the guinea pig prostaglandins cannot be regarded as chemical mediators which act directly on the vascular endothelium as do histamine, serotonin (5-hydroxytryptamine) and bradykinin.


Prostaglandin F2α reduces the bradykinin response in rat skin but not in rat paws, and markedly reduces the response of the skin to dextran, 5‐hydroxytryptamine and histamine.

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

  • C. WinterE. RisleyG. Nuss
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1962
The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.

Prostaglandins, Aspirin-like Drugs and the Oedema of Inflammation

Observations have added force to the theory that prostaglandins of the E series cause an inflammatory response in the skin of rats and man and a fever in cats15,16 and man17.

Macrophages synthesise and release prostaglandins in response to inflammatory stimuli

It is shown that macrophages whose phospholipid components were labelled with3H-arachidonic acid also synthesise and release 3H-prostaglandins (PGs) in response to inflammatory stimuli, consistent with the findings that human Macrophages on intrauterine devices and guinea pig macrophage responding to lymphokines release PGs.