Prostaglandin I2 Analogs Suppress Tumor Necrosis Factor α Production and the Maturation of Human Monocyte-Derived Dendritic Cells

  title={Prostaglandin I2 Analogs Suppress Tumor Necrosis Factor α Production and the Maturation of Human Monocyte-Derived Dendritic Cells},
  author={Ching-Hui Yeh and Chang-Hung Kuo and S. Yang and Ming-Yii Huang and Hsaing-Chi Wu and Hsing-Pi Wang and Thai-Hung Kuo and C. Hung},
  journal={Journal of Investigative Medicine},
  pages={1109 - 1115}
  • Ching-Hui Yeh, Chang-Hung Kuo, +5 authors C. Hung
  • Published 2011
  • Medicine, Biology
  • Journal of Investigative Medicine
  • Background Dendritic cells (DCs) are professional antigen-presenting cells and have critical roles in regulating immune responses. Prostaglandin I2 (PGI2) analogs are considered to be potential treatments for asthma. However, the effect of PGI2 analogs on human monocyte-derived DCs (MDDCs) is still not clearly understood. Methods Human MDDCs were pretreated with iloprost and treprostinil (2 PGI2 analogs) or forskolin (an adenyl cyclase activator) before lipopolysaccharide (LPS) stimulation. In… CONTINUE READING
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