Prostaglandin H2 as an endothelium-derived contracting factor and its interaction with endothelium-derived nitric oxide.

@article{Ito1991ProstaglandinHA,
  title={Prostaglandin H2 as an endothelium-derived contracting factor and its interaction with endothelium-derived nitric oxide.},
  author={Toshihiro Ito and Taro Kato and Yoshitaka Iwama and Masashi Muramatsu and Kimiya Shimizu and Hiroshi Asano and Kenji Okumura and Hisakuni Hashimoto and Tatsuo Satake},
  journal={Journal of hypertension},
  year={1991},
  volume={9 8},
  pages={729-36}
}
The possibility that prostaglandin H2 is an endothelium-derived contracting factor (EDCF) was evaluated in rings of thoracic aorta of spontaneously hypertensive rats (SHR). When the aortic rings were contracted with norepinephrine (10(-7) mol/l) and treated with acetylcholine (10(-5) mol/l), a relaxant response with a peak after approximately 1 min and a contractile response with a peak after approximately 7 min were observed. When these rings were pretreated with a thromboxane A2/prostaglandin… CONTINUE READING

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