Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia.

@article{Lin2002ProstaglandinHS,
  title={Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia.},
  author={Henry W. J. Lin and Karen M Lakkides and Temitope O. Keku and Srinivasa T. Reddy and Andrew D Louie and Irving H Kau and Haiyan Zhou and Jason S Y Gim and Hoang L Ma and Carl F. Matthies and Aihua Dai and Hsiao-fen Huang and Alicia M. Materi and Jesse H Lin and Harold D. Frankl and Eric C. Lee and Steven I Hardy and Harvey R. Herschman and Brian E. Henderson and Laurence N. Kolonel and Lo{\"i}c Le Marchand and R. Michael Garavito and Robert S. Sandler and Robert W Haile and William Leo Smith},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2002},
  volume={11 11},
  pages={1305-15}
}
Prostaglandin H synthase 2 (also known as cyclooxygenase-2) is thought to play a role in the prevention of colon cancer by aspirin, an inhibitor of the enzyme. We used DNA heteroduplex analysis to screen the prostaglandin H synthase 2 gene, to search for naturally occurring enzyme variants that may simulate the effects of aspirin. We found among African-Americans a single-nucleotide polymorphism that changes valine to alanine at residue 511 (V511A; GTT>GCT; g.5939T>C; allele frequency 0.045… CONTINUE READING

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