Prostaglandin H synthase: resolved and unresolved mechanistic issues.

  title={Prostaglandin H synthase: resolved and unresolved mechanistic issues.},
  author={Ah-lim Tsai and Richard J. Kulmacz},
  journal={Archives of biochemistry and biophysics},
  volume={493 1},
The cyclooxygenase and peroxidase activities of prostaglandin H synthase (PGHS)-1 and -2 have complex kinetics, with the cyclooxygenase exhibiting feedback activation by product peroxide and irreversible self-inactivation, and the peroxidase undergoing an independent self-inactivation process. The mechanistic bases for these complex, non-linear steady-state kinetics have been gradually elucidated by a combination of structure/function, spectroscopic and transient kinetic analyses. It is now… CONTINUE READING
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