Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer's disease severity.

@article{ZagolIkapitte2005ProstaglandinHA,
  title={Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer's disease severity.},
  author={Ir{\`e}ne Zagol-Ikapitte and Tina S Masterson and Venkataraman Amarnath and Thomas J. Montine and Katrin I. Andreasson and Olivier Boutaud and John A. Oates},
  journal={Journal of neurochemistry},
  year={2005},
  volume={94 4},
  pages={1140-5}
}
The formation of cyclooxygenase-derived lipid adducts of protein in brains of patients who had Alzheimer's disease has been investigated. The enzymatic product of the cyclooxygenases, prostaglandin H2, rearranges in part to highly reactive gamma-ketoaldehydes, levuglandin (LG) E(2) and LGD(2). These gamma-ketoaldehydes react with free amines on proteins to… CONTINUE READING