Prostaglandin F2alpha involves heparan sulphate sugar chains and FGFRs to modulate osteoblast growth and differentiation.

@article{Sabbieti2008ProstaglandinFI,
  title={Prostaglandin F2alpha involves heparan sulphate sugar chains and FGFRs to modulate osteoblast growth and differentiation.},
  author={Maria Giovanna Sabbieti and Dimitrios Agas and Stefano Materazzi and Mariolina Capacchietti and Giovanni Materazzi and Marja Marie Hurley and Giovanna Menghi and Luigi Marchetti},
  journal={Journal of cellular physiology},
  year={2008},
  volume={217 1},
  pages={
          48-59
        }
}
The present investigation extends our previous studies on PGF2alpha-mediated signalling in osteoblast metabolism. In particular, the role of PGF2alpha as modulator of heparan sulphate proteoglycans (HSPGs), fibroblast growth factor 2 (FGF-2) and fibroblast growth factor receptors (FGFRs) was evaluated. We hereby reported the novel observation that PGF2alpha was able to promote the formation of HSPGs/FGF-2/FGFRs complexes. Moreover, our data suggested that PGF2alpha could induce new synthesis of… CONTINUE READING
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