Prostaglandin F2alpha-F-prostanoid receptor signaling promotes neutrophil chemotaxis via chemokine (C-X-C motif) ligand 1 in endometrial adenocarcinoma.

@article{Wallace2009ProstaglandinFR,
  title={Prostaglandin F2alpha-F-prostanoid receptor signaling promotes neutrophil chemotaxis via chemokine (C-X-C motif) ligand 1 in endometrial adenocarcinoma.},
  author={Alison E. Wallace and Kurt Jason Sales and Roberto D. Catalano and Richard A. Anderson and Alistair R W Williams and Martin R. Wilson and Jurgen Schwarze and Hongwei Wang and Adriano G Rossi and Henry N. Jabbour},
  journal={Cancer research},
  year={2009},
  volume={69 14},
  pages={5726-33}
}
The prostaglandin F(2alpha) (PGF(2alpha)) receptor (FP) is elevated in endometrial adenocarcinoma. This study found that PGF(2alpha) signaling via FP regulates expression of chemokine (C-X-C motif) ligand 1 (CXCL1) in endometrial adenocarcinoma cells. Expression of CXCL1 and its receptor, CXCR2, are elevated in cancer tissue compared with normal endometrium and localized to glandular epithelium, endothelium, and stroma. Treatment of Ishikawa cells stably transfected with the FP receptor (FPS… CONTINUE READING

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