Prostaglandin F2 alpha receptors in the human trabecular meshwork.

  title={Prostaglandin F2 alpha receptors in the human trabecular meshwork.},
  author={Todd L Anthony and Kristen L. Pierce and William Daniel Stamer and John W. Regan},
  journal={Investigative ophthalmology & visual science},
  volume={39 2},
PURPOSE Prostaglandin F2 alpha (PGF2 alpha) and analogs, such as latanoprost, are thought to lower intraocular pressure (IOP), primarily by increasing uveoscleral outflow. However, outflow through the trabecular meshwork may be increased as well. The authors hypothesize that any effect on the trabecular meshwork is mediated by prostanoid FP receptors (receptors for prostaglandin F2 alpha) in this tissue. METHODS To test this hypothesis, tissue sections of the human trabecular meshwork and… CONTINUE READING


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