Prostaglandin F-2 alpha functions as a local hormone on human airways.

  title={Prostaglandin F-2 alpha functions as a local hormone on human airways.},
  author={Harold H. Newball and Harry R. Keiser and Claude Lenfant},
  journal={Respiration physiology},
  volume={41 2},
Vasoactive hormones may be classified either as 'local' or as 'circulating', depending on whether they are or are not removed by the pulmonary circulation. Prostaglandin F-2 alpha is partially removed by the human pulmonary circulation. We examined the hypothesis that, with respect to the human lung, PGF-2 alpha functions as a local mediator. Prostaglandin F-2 alpha was given to normal and asthmatic subjects via both intravenous and aerosolized routes, and we measured specific airway… CONTINUE READING


Publications citing this paper.

Similar Papers

Loading similar papers…