Prostaglandin F(2alpha) receptor-dependent regulation of prostaglandin transport.

  title={Prostaglandin F(2alpha) receptor-dependent regulation of prostaglandin transport.},
  author={Roberta Vezza and Joshua Rokach and Garret A. FitzGerald},
  journal={Molecular pharmacology},
  volume={59 6},
Prostaglandin (PG) F(2alpha) may act on its G protein-coupled receptor (FP) or be imported intracellularly via a transporter, which has high affinity for PGF(2alpha) and PGE(2), but not prostacyclin (PGI(2)). In cells overexpressing the epitope-tagged FP together with the human prostaglandin transporter (hPGT), stimulation of the FP with PGF(2alpha) (1 nM-1 microM), or the less potent FP agonist, the isoprostane 8,12-iso-iPF(2alpha)-III, inhibited prostaglandin uptake via the hPGT. This effect… CONTINUE READING