Prostaglandin EP1 receptor down-regulates expression of cyclooxygenase-2 by facilitating its proteasomal degradation.

@article{Haddad2012ProstaglandinER,
  title={Prostaglandin EP1 receptor down-regulates expression of cyclooxygenase-2 by facilitating its proteasomal degradation.},
  author={Ariz Haddad and Galit Flint-Ashtamker and Waleed Minzel and Rapita Sood and Gilad Rimon and Liza Barki-Harrington},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 21},
  pages={17214-23}
}
The enzyme cyclooxygenase-2 (COX-2) is rapidly and transiently up-regulated by a large variety of signals and implicated in pathologies such as inflammation and tumorigenesis. Although many signals cause COX-2 up-regulation, much less is known about mechanisms that actively down-regulate its expression. Here we show that the G protein-coupled receptor prostaglandin E(1) (EP(1)) reduces the expression of COX-2 in a concentration-dependent manner through a mechanism that does not require receptor… CONTINUE READING
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