Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases.

  title={Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases.},
  author={Jean Y Park and Michael H. Pillinger and Steven B. Abramson},
  journal={Clinical immunology},
  volume={119 3},
Prostaglandin E2 (PGE2) is a principal mediator of inflammation in diseases such as rheumatoid arthritis and osteoarthritis. Nonsteroidal anti-inflammatory medications (NSAIDs) and selective cyclooxygenase-2 (COX-2) inhibitors reduce PGE2 production to diminish the inflammation seen in these diseases, but have toxicities that may include both gastrointestinal bleeding and prothrombotic tendencies. In cells, arachidonic acid is transformed into PGE2 via cyclooxygenase (COX) enzymes and terminal… CONTINUE READING
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