Prostaglandin E2 stimulates bone sialoprotein (BSP) expression through cAMP and fibroblast growth factor 2 response elements in the proximal promoter of the rat BSP gene.

@article{Samoto2003ProstaglandinES,
  title={Prostaglandin E2 stimulates bone sialoprotein (BSP) expression through cAMP and fibroblast growth factor 2 response elements in the proximal promoter of the rat BSP gene.},
  author={Hiroshi Samoto and Emi Shimizu and Yuko Matsuda-Honjyo and Ryoichiro Saito and Sumi Nakao and Muneyoshi Yamazaki and Shunsuke Furuyama and Hiroshi Sugiya and Jaro Sodek and Yorimasa Ogata},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 31},
  pages={28659-67}
}
Bone sialoprotein (BSP), an early marker of osteoblast differentiation, has been implicated in the nucleation of hydroxyapatite during de novo bone formation. Prostaglandin E2 (PGE2) has anabolic effects on proliferation and differentiation of osteoblasts via diverse signal transduction systems. Because PGE2 increases the proportion of functional… CONTINUE READING