Prostaglandin E2 signaling through E prostanoid receptor 2 impairs proliferative response of double negative regulatory T cells.

@article{Lee2009ProstaglandinES,
  title={Prostaglandin E2 signaling through E prostanoid receptor 2 impairs proliferative response of double negative regulatory T cells.},
  author={Boris P-L Lee and Stephen C. Juvet and Li Zhang},
  journal={International immunopharmacology},
  year={2009},
  volume={9 5},
  pages={534-9}
}
Limited data are available on the mechanisms that constrain the function of regulatory populations of T cells. Prostaglandin E2 (PGE2) is an endogenous membrane phospholipid metabolite that has important immunomodulatory effects on T cell function. Our previous microarray data indicated that E prostanoid receptor 2 (EP2), a receptor for PGE2, is expressed by regulatory alphabetaTCR(+) CD4(-) CD8(-) NK1.1(-) double negative T (DN Treg) cell clones but not by their non-regulatory natural mutants… CONTINUE READING

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Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2009
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