Prostaglandin E2 promotes the survival of bone marrow-derived dendritic cells.

  title={Prostaglandin E2 promotes the survival of bone marrow-derived dendritic cells.},
  author={Evros K. Vassiliou and Vikas Sharma and Huie Jing and Farzad Sheibanie and Doina Ganea},
  journal={Journal of immunology},
  volume={173 11},
Since dendritic cells (DC) participate in both innate and adaptive immunity, their survival and expansion is tightly controlled. Little is known about the mechanisms of DC apoptosis. PGE(2), an arachidonic acid metabolite, plays an essential role in DC migration. We propose a novel function for PGE(2) as a DC survival factor. Our studies demonstrate that PGE(2) protects DC in vitro against apoptosis induced by withdrawal of growth factors or ceramide. DC matured in conditions that inhibit… CONTINUE READING
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