Prostaglandin E2 promotes the cell growth and invasive ability of hepatocellular carcinoma cells by upregulating c-Myc expression via EP4 receptor and the PKA signaling pathway.

@article{Xia2014ProstaglandinEP,
  title={Prostaglandin E2 promotes the cell growth and invasive ability of hepatocellular carcinoma cells by upregulating c-Myc expression via EP4 receptor and the PKA signaling pathway.},
  author={Shukai Xia and J. Ma and X. Bai and H. Zhang and Shanyu Cheng and Min Zhang and L. Zhang and Ming-zhan Du and Yipin Wang and H. Li and Rong Rong and Feng Shi and Q. Yang and J. Leng},
  journal={Oncology reports},
  year={2014},
  volume={32 4},
  pages={
          1521-30
        }
}
Hepatocellular carcinoma (HCC) represents a major health problem worldwide. Prostaglandin E2 (PGE2), the predominant product of cyclooxygenase-2, has been implicated in hepatocarcinogenesis. However, the underlying molecular mechanisms remain to be further elucidated. c-myc, a cellular proto-oncogene, is activated or overexpressed in many types of human cancer, including HCC. The present study was designed to investigate the internal relationship and molecular mechanisms between PGE2 and c-Myc… Expand
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