Prostaglandin E2 promotes hepatocellular carcinoma cell invasion through upregulation of YB-1 protein expression.

@article{Zhang2014ProstaglandinEP,
  title={Prostaglandin E2 promotes hepatocellular carcinoma cell invasion through upregulation of YB-1 protein expression.},
  author={Hai Zhang and Shanyu Cheng and Min Zhang and Xiuping Ma and Li Zhang and Yipin Wang and Rong Rong and Juan Ma and Shukai Xia and Mingzhan Du and Feng Shi and Jie Wang and Qinyi Yang and Xiaoming Bai and Jing Leng},
  journal={International journal of oncology},
  year={2014},
  volume={44 3},
  pages={769-80}
}
Prostaglandin E2 (PGE2) has been implicated in hepatocellular carcinoma cell invasion. Recently, it was reported that Y box-binding protein 1 (YB-1) is closely correlated with malignancy. This study was designed to examine the mechanisms by which PGE2 increases YB-1 expression and promotes HCC cell invasion. PGE2 greatly enhanced HCC cell invasion through upregulation of the YB-1 protein, and the EP1 receptor is mainly responsible for this regulation. Src and EGFR were both activated by PGE2… CONTINUE READING

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