Prostaglandin E2 promotes embryonic vascular development and maturation in zebrafish

@article{Ugwuagbo2019ProstaglandinEP,
  title={Prostaglandin E2 promotes embryonic vascular development and maturation in zebrafish},
  author={Kingsley Chukwunonso Ugwuagbo and Sujit Maiti and Ahmed Mohamed Omar and Stephanie Hunter and Braydon Nault and Caleb Northam and Mousumi Majumder},
  journal={Biology Open},
  year={2019},
  volume={8}
}
ABSTRACT Prostaglandin (PG)-E2 is essential for growth and development of vertebrates. PGE2 binds to G-coupled receptors to regulate embryonic stem cell differentiation and maintains tissue homeostasis. Overproduction of PGE2 by breast tumor cells promotes aggressive breast cancer phenotypes and tumor-associated lymphangiogenesis. In this study, we investigated novel roles of PGE2 in early embryonic vascular development and maturation with the microinjection of PGE2 in fertilized zebrafish… 
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References

SHOWING 1-10 OF 61 REFERENCES
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
TLDR
The conserved role for PGE2 in the regulation of vertebrate HSC homeostasis indicates that modulation of the prostaglandin pathway may facilitate expansion of HSC number for therapeutic purposes.
Discovery and Characterization of Novel Vascular and Hematopoietic Genes Downstream of Etsrp in Zebrafish
TLDR
A group of genes downstream of etsrp likely to be critical for vascular and/or myeloid development are identified, with six of these being completely novel.
Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration
TLDR
It is shown that wnt reporter activity in zebrafish HSCs is responsive to PGE2 modulation, demonstrating a direct interaction in vivo and suggesting the P GE2/Wnt interaction is a master regulator of vertebrate regeneration and recovery.
Zebrafish G protein γ2 is required for VEGF signaling during angiogenesis
TLDR
It is shown that targeted knockdown of the G protein gng2 gene (Gγ2) blocks the normal angiogenic process in developing zebrafish embryos, which provides a new opportunity for cotargeting G protein- and VEGF-dependent pathways to synergistically block pathologic angiogenesis.
Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish.
TLDR
This work describes a mutation in the zebrafish vegf receptor-2 homolog, kdra, which eliminates its kinase activity and leads to specific defects in artery development and suggests a genetic mechanism for generating blood vessel diversity during vertebrate development.
Zebrafish as an Emerging Model Organism to Study Angiogenesis in Development and Regeneration
TLDR
This review addresses and compares the most commonly used experimental models to study angiogenesis in vitro and in vivo and focuses on the implementation of the zebrafish (Danio rerio) as a model to studyAngiogenesis and discusses the advantages and not yet explored possibilities of its use as model organism.
ETS transcription factor Etsrp / Etv2 is required for lymphangiogenesis and directly regulates vegfr3 / flt4 expression.
The molecular mechanisms initiating the formation of the lymphatic system, lymphangiogenesis, are still poorly understood. Here we have identified a novel role in lymphangiogenesis for an ETS
Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development
TLDR
Zebrafish vegfd mutants display significant defects in facial lymphangiogenesis independent of vegfc function, demonstrating that, rather than being dispensable during development, Vegfd plays context-specific indispensable and also compensatory roles during both blood vessel angiogenesis and lymphang iogenesis.
Development of the larval lymphatic system in zebrafish
TLDR
Generation of a zebrafish transgenic line expressing GFP in lymphatic vessels allows visualization of the developing lymphatic network, demonstrating a stereotyped, stepwise assembly.
Vegf signaling promotes vascular endothelial differentiation by modulating etv2 expression.
TLDR
A revised model is proposed which explains the different phenotypes observed upon inhibition of Vegf signaling: low levels of Veg f signaling promote overall vascular endothelial differentiation and cell survival by upregulating etv2 expression, while high levels of vegf signaling promote arterial and inhibit venous specification.
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