Prostaglandin E2 production and metabolism in human breast cancer cells and breast fibroblasts. Regulation by inflammatory mediators.

@article{Schrey1995ProstaglandinEP,
  title={Prostaglandin E2 production and metabolism in human breast cancer cells and breast fibroblasts. Regulation by inflammatory mediators.},
  author={Michael P. Schrey and K. V. Patel},
  journal={British Journal of Cancer},
  year={1995},
  volume={72},
  pages={1412 - 1419}
}
Malignant human breast tumours contain high levels of prostaglandin E2 (PGE2). However, the mechanisms controlling PGE2 production in breast cancer are unknown. This in vitro study investigates the capacity for PGE2 synthesis and metabolism in several human breast cancer cell lines and early passage human breast fibroblasts and seeks to identify potential regulatory factors which may control these pathways. Basal PGE2 production rose up to 30-fold in breast fibroblast lines on addition of… Expand
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15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression
  • Eun Ji Lee, Su-Jung Kim, +8 authors Y. Surh
  • Medicine, Chemistry
  • Redox biology
  • 2019
TLDR
Thiol modification of STAT3 by 15-keto PGE2 inactivates STAT3 which may account for its suppression of breast cancer cell proliferation and progression. Expand
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