Prostaglandin E2 is crucial in the response of podocytes to fluid flow shear stress

  title={Prostaglandin E2 is crucial in the response of podocytes to fluid flow shear stress},
  author={Tarak Srivastava and Ellen T. McCarthy and Ram Sharma and Patricia A. Cudmore and Mukut Lal Sharma and Mark L. Johnson and Lynda F. Bonewald},
  journal={Journal of Cell Communication and Signaling},
Podocytes play a key role in maintaining and modulating the filtration barrier of the glomerulus. Because of their location, podocytes are exposed to mechanical strain in the form of fluid flow shear stress (FFSS). Several human diseases are characterized by glomerular hyperfiltration, such as diabetes mellitus and hypertension. The response of podocytes to FFSS at physiological or pathological levels is not known. We exposed cultured podocytes to FFSS, and studied changes in actin cytoskeleton… CONTINUE READING
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Shear force induces c-src phosphorylation and phospholipase D activation in differentiated podocytes

  • C Huang, RT Miller
  • J Am Soc Nephrol 18:209A
  • 2007
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