Prostaglandin E2 inhibits renal collecting duct Na+ absorption by activating the EP1 receptor.

@article{Guan1998ProstaglandinEI,
  title={Prostaglandin E2 inhibits renal collecting duct Na+ absorption by activating the EP1 receptor.},
  author={Youfei Guan and Yan Hong Zhang and Richard M Breyer and Beth Fowler and Linda Davis and Richard L. H{\'e}bert and Matthew D. Breyer},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={102 1},
  pages={194-201}
}
PGE2 exerts potent diuretic and natriuretic effects on the kidney. This action is mediated in part by direct inhibition of collecting duct Na+ absorption via a Ca++-coupled mechanism. These studies examine the role the Ca++-coupled PGE-E EP1 receptor plays in mediating these effects of PGE2 on Na+ transport. Rabbit EP1 receptor cDNA was amplified from rabbit kidney RNA. Nuclease protection assays demonstrated highest expression of EP1 mRNA in kidney, followed by stomach, adrenal, and ileum. In… CONTINUE READING

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