Prostaglandin E2 inhibits proliferation and migration of HTR-8/SVneo cells, a human trophoblast-derived cell line.

@article{Biondi2006ProstaglandinEI,
  title={Prostaglandin E2 inhibits proliferation and migration of HTR-8/SVneo cells, a human trophoblast-derived cell line.},
  author={Carla Biondi and Maria Enrica Ferretti and Barbara Pavan and Laura Lunghi and B Gravina and Milena Sabrina Nicoloso and Fortunato Vesce and Gustavo Baldassarre},
  journal={Placenta},
  year={2006},
  volume={27 6-7},
  pages={592-601}
}
Normal placentation requires a highly coordinated control of proliferation, migration and invasiveness of extravillous trophoblast cells. Since prostaglandin E2 is a major prostanoid synthesized by intrauterine tissues and highly involved in pregnancy homeostasis, we examined the possibility that it modulates extravillous trophoblast cell functions. Here, we report the presence of mRNAs for prostaglandin E2 EP2 and EP4 receptor isoforms and of proteins in both first-trimester human chorionic… CONTINUE READING

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