Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

@article{Betz1991ProstaglandinEI,
  title={Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.},
  author={Michael Betz and Barbara S. Fox},
  journal={Journal of immunology},
  year={1991},
  volume={146 1},
  pages={108-13}
}
PGE2 is known to inhibit IL-2 and IFN-gamma production from Th cells and is widely viewed as a general immunosuppressant. However, PGE2 was found not to inhibit IL-4 production from Th2 clones, and IL-5 production from these clones was slightly enhanced. The same results were obtained with short term T cell lines, which indicates that the lack of inhibition of IL-4 and IL-5 production by PGE2 is a general phenomenon. PGE2 functions by increasing cAMP levels through activation of adenylate… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 234 extracted citations

Similar Papers

Loading similar papers…