Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: a novel mechanism for the regulation of aromatase in obesity and breast cancer.

@article{Wang2015ProstaglandinEI,
  title={Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: a novel mechanism for the regulation of aromatase in obesity and breast cancer.},
  author={Xuyi Wang and Maria M. Docanto and Hironobu Sasano and Camden Yeung-Wah Lo and Evan R. Simpson and Kristy A. Brown},
  journal={Cancer research},
  year={2015},
  volume={75 4},
  pages={645-55}
}
Obesity is a risk factor for postmenopausal breast cancer and the majority of these cancers are estrogen dependent. Aromatase converts androgens into estrogens and its increased expression in breast adipose stromal cells (ASC) is a major driver of estrogen receptor-positive breast cancer. In particular, obesity-associated and tumor-derived factors, such as prostaglandin E2 (PGE2), have been shown to drive the expression of aromatase by stimulating the activity of the proximal promoter II (PII… CONTINUE READING

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