Prostaglandin E2 inhibits human T-cell proliferation after crosslinking of the CD3-Ti complex by directly affecting T cells at an early step of the activation process.

@article{Vercammen1987ProstaglandinEI,
  title={Prostaglandin E2 inhibits human T-cell proliferation after crosslinking of the CD3-Ti complex by directly affecting T cells at an early step of the activation process.},
  author={C Vercammen and Jan L Ceuppens},
  journal={Cellular immunology},
  year={1987},
  volume={104 1},
  pages={
          24-36
        }
}
We have studied the effects of prostaglandin E2 (PGE2) on in vitro human T-cell activation induced by crosslinking of the CD3-Ti complex with the monoclonal anti-CD3 antibodies OKT3 and UCHT-1. PGE2 (greater than or equal to 3 X 10(-9) M) when added simultaneously with anti-CD3 to cultures of peripheral blood mononuclear cells (PBMC), significantly suppressed, in a dose-dependent way, T-cell proliferation (P less than 0.002). However, when T cells were first preactivated with OKT3 for 3 days… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function.

  • Frontiers in bioscience : a journal and virtual library
  • 2004
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Aging Leads to Disturbed Homeostasis of Memory Phenotype CD8+ Cells

  • The Journal of experimental medicine
  • 2002
VIEW 1 EXCERPT
CITES BACKGROUND