Prostaglandin E2 induces spontaneous rhythmic activity in mouse urinary bladder independently of efferent nerves.

@article{Kobayter2012ProstaglandinEI,
  title={Prostaglandin E2 induces spontaneous rhythmic activity in mouse urinary bladder independently of efferent nerves.},
  author={S Kobayter and John S. Young and Keith L. Brain},
  journal={British journal of pharmacology},
  year={2012},
  volume={165 2},
  pages={401-13}
}
BACKGROUND AND PURPOSE The acute effects of PGE(2) on bladder smooth muscle and nerves were examined to determine the origin of PGE(2)-induced spontaneous rhythmic contractions. EXPERIMENTAL APPROACH Contraction studies, confocal Ca(2+) imaging and electrophysiological recordings in strips of mouse urinary bladder were used to differentiate the effects of PGE(2) on bladder smooth muscle and efferent nerves. KEY RESULTS PGE(2) (50 µM) increased the tone and caused phasic contractions of… CONTINUE READING