Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases.

@article{Rsch2005ProstaglandinEI,
  title={Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases.},
  author={Susanne R{\"o}sch and R. Ramer and K. Brune and B. Hinz},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={338 2},
  pages={
          1171-8
        }
}
Prostaglandins (PGs) have been implicated in lowering intraocular pressure (IOP). A possible role of cyclooxygenase-2 (COX-2) in this process was emphasized by findings showing impaired COX-2 expression in the non-pigmented ciliary epithelium (NPE) of patients with primary open-angle glaucoma. The present study investigates the effect of the major COX-2 product, PGE(2), on the expression of its synthesizing enzyme in human NPE cells (ODM-2). PGE(2) led to an increase of COX-2 mRNA and protein… Expand
Prostaglandin pathway gene therapy for sustained reduction of intraocular pressure.
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References

SHOWING 1-10 OF 44 REFERENCES
Latanoprost induces matrix metalloproteinase‐1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase‐2‐dependent mechanism
Prostaglandin E2 Regulates the Level and Stability of Cyclooxygenase-2 mRNA through Activation of p38 Mitogen-activated Protein Kinase in Interleukin-1β-treated Human Synovial Fibroblasts*
  • Wissam H. Faour, Yulan He, +4 authors John A. Di Battista
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2001
Expression of cyclooxygenase-1 and -2 in normal and glaucomatous human eyes.
PGE2-induced hypertrophy of cardiac myocytes involves EP4 receptor-dependent activation of p42/44 MAPK via EGFR transactivation
  • M. Mendez, M. Lapointe
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
  • 2005
...
1
2
3
4
5
...