Prostaglandin E2 increases growth and motility of colorectal carcinoma cells.

@article{Sheng2001ProstaglandinEI,
  title={Prostaglandin E2 increases growth and motility of colorectal carcinoma cells.},
  author={Hongmiao Sheng and Jianhua Shao and M. Kay Washington and Raymond N. Dubois},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 21},
  pages={
          18075-81
        }
}
Chronic use of nonsteroidal anti-inflammatory drugs results in a significant reduction of risk and mortality from colorectal cancer in humans. All of the mechanism(s) by which nonsteroidal anti-inflammatory drugs exert their protective effects are not completely understood, but they are known to inhibit cyclooxygenase activity. The cyclooxygenase enzymes catalyze a key reaction in the conversion of arachidonic acid to prostaglandins, such as prostaglandin E(2) (PGE(2)). Here we demonstrate that… CONTINUE READING
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