Prostaglandin E2 formation by the gall bladder in experimental cholecystitis.

@article{Thornell1986ProstaglandinEF,
  title={Prostaglandin E2 formation by the gall bladder in experimental cholecystitis.},
  author={E Thornell and Lennart Jiveg{\aa}rd and Klaus Bukhave and J{\o}rgen Rask-Madsen and Joar Svanvik},
  journal={Gut},
  year={1986},
  volume={27 4},
  pages={
          370-3
        }
}
Both experimental cholecystitis and luminal distension inhibit fluid absorption and stimulate motor activity in the gall bladder. These functional alterations are mimicked by exogenous prostaglandins (PGs) and inhibited by potent cyclooxygenase inhibitors, but direct evidence of a primary role of endogenous PGs is not available. Therefore, experiments in the cat were carried out in which the effects of lyso-phosphatidylcholine (lysoPC; 0.5-2.0 mmol/l), implantation of cholesterol stones, and… CONTINUE READING

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