Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models.

@article{Goessling2011ProstaglandinEE,
  title={Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models.},
  author={Wolfram Goessling and Robyn S. Allen and Xiao Ting Guan and Ping Jin and Nobuko Uchida and Michael Christian Dovey and Jeremy M. Harris and Mark E. Metzger and Aylin C. Bonifacino and David E Stroncek and Joseph J Stegner and Myriam Armant and Thorsten M. Schlaeger and John F. Tisdale and Leonard I. Zon and Robert E Donahue and Trista E. North},
  journal={Cell stem cell},
  year={2011},
  volume={8 4},
  pages={
          445-58
        }
}
Hematopoietic stem cells (HSCs) are used in transplantation therapy to reconstitute the hematopoietic system. Human cord blood (hCB) transplantation has emerged as an attractive alternative treatment option when traditional HSC sources are unavailable; however, the absolute number of hCB HSCs transplanted is significantly lower than bone marrow or mobilized peripheral blood stem cells (MPBSCs). We previously demonstrated that dimethyl-prostaglandin E2 (dmPGE2) increased HSCs in vertebrate… CONTINUE READING
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