Prostaglandin E2 and prostacyclin inhibit the production and secretion of endothelin from cultured endothelial cells.

@article{Prins1994ProstaglandinEA,
  title={Prostaglandin E2 and prostacyclin inhibit the production and secretion of endothelin from cultured endothelial cells.},
  author={Bruce Prins and Renming Hu and B Nazario and Ali Pedram and Hermann Frank and Marietta A Weber and Ellis Robert Levin},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 16},
  pages={11938-44}
}
Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor yet identified. This peptide plays an important role in the regulation of arterial tone, in part through its interaction with endogenous vasodilator compounds. To understand the interactions of endothelin with the vasoactive prostaglandins (PGs), we determined the effects of prostaglandin E2 (PGE2), prostacyclin (PGI2), and thromboxane A2 on ET-1 synthesis and secretion from cultured bovine aortic endothelial cells and on ET-1… CONTINUE READING