Prostaglandin E2 and IL-23 interconnects STAT3 and RoRγ pathways to initiate Th17 CD4+ T-cell development during rheumatoid arthritis

@article{Samuels2018ProstaglandinEA,
  title={Prostaglandin E2 and IL-23 interconnects STAT3 and RoRγ pathways to initiate Th17 CD4+ T-cell development during rheumatoid arthritis},
  author={Janaiya S Samuels and Lauren Holland and Mar{\'i}a L{\'o}pez and Keya R Meyers and William G. Cumbie and Anna McClain and Aleksandra Ignatowicz and Daryllynn Nelson and Rangaiah Shashidharamurthy},
  journal={Inflammation Research},
  year={2018},
  volume={67},
  pages={589-596}
}
BackgroundThe chronic inflammation associated with rheumatoid arthritis (RA) leads to focal and systemic bone erosion of the joints resulting in a crippling disability. Recent reports indicate an increase in the incidence of RA in the coming years, placing a significant burden on healthcare resources. The incidence of RA is observed to be increasing with age and a significant proportion of those new cases will be aggressively erosive.FindingsThe altered physiology, due to immune disturbances… CONTINUE READING

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