Prostaglandin E2 and I2 treatment of acute experimental pancreatitis in rats.

@article{Olazbal1986ProstaglandinEA,
  title={Prostaglandin E2 and I2 treatment of acute experimental pancreatitis in rats.},
  author={Angel Olaz{\'a}bal},
  journal={Pancreas},
  year={1986},
  volume={1 6},
  pages={529-35}
}
Acute pancreatitis can be induced experimentally in rats by the retrograde pancreatic duct injection of deoxycholic acid. In order to evaluate if prostaglandins have a protective or therapeutic role, pancreatitis was induced with 0.03, 0.1, or 0.2 ml of 3% deoxycholic acid. Then, 16,16 dimethyl prostaglandin E2 or prostaglandin I2 were infused i.v. for 30 min before the deoxycholic acid injection or for 1 or 24 h beginning 30 min or 1 h after the injection. Deoxycholic acid, 0.1 and 0.2 ml… CONTINUE READING