Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages.

@article{Sokolowska2015ProstaglandinEI,
  title={Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages.},
  author={Milena Sokolowska and Li-Yuan Chen and Yueqin Liu and Asunci{\'o}n Mart{\'i}nez-Ant{\'o}n and Hai-Yan Qi and Carolea Logun and Sara Alsaaty and Yong Hwan Park and Daniel L. Kastner and Jae Jin Chae and James H. Shelhamer},
  journal={Journal of immunology},
  year={2015},
  volume={194 11},
  pages={
          5472-5487
        }
}
PGE2 is a potent lipid mediator involved in maintaining homeostasis but also promotion of acute inflammation or immune suppression in chronic inflammation and cancer. Nucleotide-binding domain, leucine-rich repeat-containing protein (NLR)P3 inflammasome plays an important role in host defense. Uncontrolled activation of the NLRP3 inflammasome, owing to mutations in the NLRP3 gene, causes cryopyrin-associated periodic syndromes. In this study, we showed that NLRP3 inflammasome activation is… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 54 CITATIONS, ESTIMATED 49% COVERAGE

Forskolin attenuates the NLRP3 inflammasome activation and IL-1β secretion in human macrophages

  • Pediatric Research
  • 2019
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome.

  • Immunity
  • 2016
VIEW 4 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2016
2019

CITATION STATISTICS

  • 3 Highly Influenced Citations

  • Averaged 11 Citations per year from 2017 through 2019