Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo.

@article{Rao2007ProstaglandinER,
  title={Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo.},
  author={Reena Rao and Reyadh Redha and Ines M Macias-Perez and Yan Su and Chuanming Hao and Roy Zent and Matthew D. Breyer and Ambra Pozzi},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 23},
  pages={16959-68}
}
Prostaglandin E2 (PGE(2)), a major product of cyclooxygenase, exerts its functions by binding to four G protein-coupled receptors (EP1-4) and has been implicated in modulating angiogenesis. The present study examined the role of the EP4 receptor in regulating endothelial cell proliferation, migration, and tubulogenesis. Primary pulmonary microvascular endothelial cells were isolated from EP4(flox/flox) mice and were rendered null for the EP4 receptor with adenoCre virus. Whereas treatment with… CONTINUE READING