Prostaglandin E2 EP2 and EP4 receptor activation mediates cAMP-dependent hyperpolarization and exocytosis of renin in juxtaglomerular cells.

@article{Friis2005ProstaglandinEE,
  title={Prostaglandin E2 EP2 and EP4 receptor activation mediates cAMP-dependent hyperpolarization and exocytosis of renin in juxtaglomerular cells.},
  author={Ulla G. Friis and Jane Stubbe and Torben R Uhrenholt and Per Svenningsen and Rolf Michael N{\"u}sing and Ole Sk\ott and Boye Lagerbon Jensen},
  journal={American journal of physiology. Renal physiology},
  year={2005},
  volume={289 5},
  pages={F989-97}
}
PGE(2) and PGI(2) stimulate renin secretion and cAMP accumulation in juxtaglomerular granular (JG) cells. We addressed, at the single-cell level, the receptor subtypes and intracellular transduction mechanisms involved. Patch clamp was used to determine cell capacitance (C(m)), current, and membrane voltage in response to PGE(2), EP2 and EP4 receptor agonists, and an IP receptor agonist. PGE(2) (0.1 micromol/l) increased C(m) significantly, and the increase was abolished by intracellular… CONTINUE READING

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