Prostaglandin E2 Differentially Modulates Proinflammatory/Prodestructive Effects of TNF-α on Synovial Fibroblasts via Specific E Prostanoid Receptors/cAMP1

@article{Kunisch2009ProstaglandinED,
  title={Prostaglandin E2 Differentially Modulates Proinflammatory/Prodestructive Effects of TNF-$\alpha$ on Synovial Fibroblasts via Specific E Prostanoid Receptors/cAMP1},
  author={Elke Kunisch and Anne Jansen and Fumiaki Kojima and Ivonne L{\"o}ffler and Mohit Kapoor and Shinichi Kawai and Ignacio Rubio and Leslie J. Crofford and Raimund W. Kinne},
  journal={The Journal of Immunology},
  year={2009},
  volume={183},
  pages={1328 - 1336}
}
The present study investigated the influence of PGE2, E prostanoid (EP) receptors, and their signaling pathways on matrix metalloproteinase (MMP)-1 and IL-6 expression in synovial fibroblasts (SFs) from rheumatoid arthritis (RA) patients. RASFs expressed all four EP receptors, with selective induction of EP2 by TNF-α. TNF-α time-dependently increased intracellular cAMP/protein kinase A signaling (maximum, 6–12 h) and PGE2 secretion (maximum, 24 h). PGE2 and the EP2 agonists butaprost or ONO-AE1… 

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