Prostaglandin E2 (PGE2) suppresses natural killer cell function primarily through the PGE2 receptor EP4

@article{Holt2011ProstaglandinE,
  title={Prostaglandin E2 (PGE2) suppresses natural killer cell function primarily through the PGE2 receptor EP4},
  author={Dawn M Holt and Xinrong Ma and Namita Kundu and Amy M. Fulton},
  journal={Cancer Immunology, Immunotherapy},
  year={2011},
  volume={60},
  pages={1577-1586}
}
The COX-2 product prostaglandin E2 (PGE2) contributes to the high metastatic capacity of breast tumors. Our published data indicate that inhibiting either PGE2 production or PGE2-mediated signaling through the PGE2 receptor EP4 reduces metastasis by a mechanism that requires natural killer (NK) cells. It is known that NK cell function is compromised by PGE2, but very little is known about the mechanism by which PGE2 affects NK effector activity. We now report the direct effects of PGE2 on the… CONTINUE READING
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