Prostaglandin E2–EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells

@article{Kabashima2003ProstaglandinES,
  title={Prostaglandin E2–EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells},
  author={Kenji Kabashima and Daiji Sakata and Miyako Nagamachi and Yoshiki Miyachi and Kayo Inaba and Shuh Narumiya},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={744-749}
}
Antigen-specific immune responses in the skin are initiated by antigen uptake into Langerhans cells and the subsequent migration of these cells to draining lymph nodes. Although prostaglandin E2 (PGE2) is produced substantially in skin exposed to antigen, its role remains unclear. Here we show that although Langerhans cells express all four PGE receptor subtypes, their migration to regional lymph nodes was decreased only in EP4-deficient (Ptger4−/−) mice and in wild-type mice treated with an… CONTINUE READING
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