Prostaglandin E synthases in zebrafish.

  title={Prostaglandin E synthases in zebrafish.},
  author={Barbara Pini and Tilo Grosser and John A. Lawson and Tom S. Price and Michael A. Pack and Garret A. FitzGerald},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={25 2},
OBJECTIVE Prostaglandin E synthases (PGESs) are being explored as antiinflammatory drug targets as alternatives to cyclooxygenase (COX)-2. Located downstream of the cyclooxygenases, PGESs catalyze PGE(2) formation, and deletion of microsomal (m)-PGES-1 abrogates inflammation. We sought to characterize the developmental expression of COX and PGES in zebrafish. METHODS AND RESULTS We cloned zebrafish cytosolic (c) and m-PGES orthologs and mapped them to syntenic regions of chromosomes 23 and 5… CONTINUE READING