Prostaglandin E receptors and the kidney.

@article{Breyer2000ProstaglandinER,
  title={Prostaglandin E receptors and the kidney.},
  author={Matthew D. Breyer and Richard M Breyer},
  journal={American journal of physiology. Renal physiology},
  year={2000},
  volume={279 1},
  pages={F12-23}
}
Prostaglandin E(2) is a major renal cyclooxygenase metabolite of arachidonate and interacts with four G protein-coupled E-prostanoid receptors designated EP(1), EP(2), EP(3), and EP(4). Through these receptors, PGE(2) modulates renal hemodynamics and salt and water excretion. The intrarenal distribution and function of EP receptors have been partially characterized, and each receptor has a distinct role. EP(1) expression predominates in the collecting duct where it inhibits Na(+) absorption… CONTINUE READING
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