Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties

@inproceedings{Kundu2013ProstaglandinER,
  title={Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties},
  author={Namita Kundu and Xinrong Ma and Tyler Justin Kochel and Olga G. Goloubeva and Paul N. Staats and Keyata N. Thompson and Stuart S. Martin and Jocelyn Christine Reader and Yukinori Take and Peter D. Collin and Amy M. Fulton},
  booktitle={Breast Cancer Research and Treatment},
  year={2013}
}
The cyclooxygenase pathway is strongly implicated in breast cancer progression but the role of this pathway in the biology of breast cancer stem/progenitor cells has not been defined. Recent attention has focused on targeting the cyclooxygenase 2 (COX-2) pathway downstream of the COX-2 enzyme by blocking the activities of individual prostaglandin E (EP) receptors. Prostaglandin E receptor 4 (EP4) is widely expressed in primary invasive ductal carcinomas of the breast and antagonizing this… CONTINUE READING
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