Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis.

  title={Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis.},
  author={Xinrong Ma and Namita Kundu and Salah Rifat and Tonya C. Walser and Amy M. Fulton},
  journal={Cancer research},
  volume={66 6},
Cyclooxygenase-2 (COX-2) expression in epithelial tumors is frequently associated with a poor prognosis. In a murine model of metastatic breast cancer, we showed that COX-2 inhibition is associated with decreased metastatic capacity. The COX-2 product, prostaglandin E(2) (PGE(2)), acts through a family of G protein-coupled receptors designated EP1-4 that mediate intracellular signaling by multiple pathways. We characterized EP receptor expression on three murine mammary tumor cell lines and… CONTINUE READING


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Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression.

Proceedings of the National Academy of Sciences of the United States of America • 2004
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