Prostaglandin E receptor EP3 subtype induces neurite retraction via small GTPase Rho.

@article{Katoh1996ProstaglandinER,
  title={Prostaglandin E receptor EP3 subtype induces neurite retraction via small GTPase Rho.},
  author={Hironori Katoh and Manabu Negishi and Atsushi Ichikawa},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 47},
  pages={29780-4}
}
Prostaglandin E receptor EP3 subtype is widely distributed in the nervous system and is specifically localized to neurons, suggesting that the EP3 receptor plays important roles in the nervous system. We established a PC12 cell line that stably expresses the EP3B receptor isoform isolated from bovine adrenal chromaffin cells and examined the effect of agonist stimulation on the neuronal morphology of the PC12 cells. In the differentiated cells, M&B28767, an EP3 agonist, caused neurite… CONTINUE READING