Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis

@inproceedings{Chang2015ProstaglandinER,
  title={Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis},
  author={Jian Cong Chang and Jean Gilles Vacher and Bing Yao and Xiaofeng Fan and Bixiang Zhang and Raymond C Harris and Ming-zhi Zhang},
  booktitle={Oncotarget},
  year={2015}
}
Colorectal cancer (CRC) continues to be a major cause of morbidity and mortality. Although the factors underlying CRC development and progression are multifactorial, there is an important role for tumor-host interactions, especially interactions with myeloid cells. There is also increasing evidence that cyclooxygenase-derived prostaglandins are important mediators of CRC development and growth. Although prevention trials with either nonselective NSAIDs or COX-2 selective agents have shown… CONTINUE READING

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